In the Indian system of medicine, giloy or guduchi also known as amrita and botanically known as Tinospora Cordifolia is a frequently used herb. It is a climber that is easily available throughout the countryside of Indian sub-continent. Clinging on to other big trees like that of margosa and mango, it throws aerial roots, thus fully casing the host plant or tree.

Guduchi or giloy or Tinospora Cordifolia is a huge, climbing shrub. Guduchi or giloy (tinospora) is one of the most important aspects of the Ayurvedic category of Rasayana, or rejuvenator tonics. This can be evaluated with the fact that it is mentioned in Charka Samhita text that is considered as the medicinal book of ayurveda. Various Studies and researches done on Guduchi's immune-boosting capacity show it to be linked to ornamental the function of protective cells called macrophages. The plant is used to perk up the immune system and the body's struggle to infections. The giloy satva (tinospora) is used in dyspepsia, fevers, and urinary diseases. Its principle constituents that makes giloy satva works are tinosporine, tinosporide, tinosporaside, cordifolide, cordifol, heptacosanol, clerodane furano diterpene, diterpenoid furanolactone tinosporidine, columbin and §-sitosterol.

Guduchi Herbal Dietary Supplement: 60 Vegetable Capsules

Packs Retail Price Sale Price Shipping Order Now 2 Bottle $35.00 $35.00 Free 3 Bottle $53.00 $47.00 Free 5 Bottles $88.00 $69.00 Free 10 Bottles $175.00 $129.00 Free

Serving size: 2 Vegi caps
Servings per container: 30
Each 500 mg capsule contains: Guduchi

Dosage: 1-2 Capsules two times a day after meal or or as directed by your health practitioner.

The active principles and juice of the fresh plant acquire a number of pharmacological actions. It is bitter, stomachic, anti-periodic, and aphrodisiac in actions. Giloy satva is useful in chronic diarrhea, to remove renal stones (Calculi), as a diuretic, Central Nervous System depressant, hypoglycemic, anti-bacterial, anti-pyretic, anti-inflammatory, anti-rheumatic, anti-allergic, analgesic, hepato-protective, and to decrease blood urea. The plant is used in Ayurvedic rasayana to progress the immune system and the body's resistance against infections. It is used as an immuno-modulator in immuno-suppression of obstructive jaundice, hepatic fibrosis, peritonitis and sepsis. The plant has been found efficient in preventing fibrous changes and promotes renewal of the liver against CCl4 induced hepato-toxicity.

Giloy satva (tinospora) has been proven to be efficient in restraining the growth of bacteria and enhancing the build-up of immune confrontation. Scientific research done by Ayurvedic doctors and research scholars has now provided evidence to Giloys’s immune-boosting ability to fight diseases. In a study using human white blood cells (WBC), Giloy augmented the killing capability of macrophages, the immune cells accountable for combating invaders.

• Guduchi is one of the most powerful immuno-booster.
• Giloy satva helps in boosting the usefulness of defensive white blood cells (WBC) and builds up the body's own security mechanism i.e. immune system.
• Giloy satva improves the performance of protective cells, macrophages, and improves body's confrontation to infections.
• It also functions as a diuretic agent, helps in removal of renal calculi and also reduces blood urea.
• Giloy stava (tinospora) restrain growth of bacteria and augments the build-up of immune confrontation.
• Giloy satva has anti-bacterial, anti-inflammatory, anti-rheumatic, and anti-allergic properties.
• Giloy Satva (tinospora) is a Tridoshic Herb. The real indication of Giloy Satva, that is also known as ‘Amrit’ in Sanskrit means ‘Ambrosia’. Giloy satva (tinospora) is helpful in treating fever, gout, jaundice, torpidity of the liver, skin related diseases, secondary syphilis, constipation, tuberculosis, and leprosy.
• Giloy satva (tinospora) is a blood purifier.

• Rasa: Tikta, Kashaya
• Guna: Laghu, Snigdha
• Veerya: Ushna
• Dosha : Doshagna, vataghna, Tridoshagna
• Karma: Deepaniya, Trishunanigrahan, Stanyabodhan, Rasayana, Jvarahara

Resreach I - G1-4A, an immuno-modulatory polysaccharide from Tinospora cordifolia (Giloy), modulates macrophage responses and protects mice against lipo-polysaccharide induced endotoxic shock.
By Desai VR, Ramkrishnan R, Chintalwar GJ, Sainis KB.

The research was carried out at Radiation Biology and Health Sciences Division, Bio-Medical Group, Mumbai, India. Pro-inflammatory cytokines are recognized to be the mediators of endotoxic shock and numerous immuno-modulatory herbs can alter the expression of these cytokines. So we have investigated the likelihood of using an arabinogalactan polysaccharide, G1-4A, from the stem of Tinospora cordifolia (Guduchi), for protection against endotoxin induced sepsis. There was 100 percent protection against lipopolysaccharide (LPS) induced mortality in mice pretreated with G1-4A. To clarify the mechanism of action, its effect on macrophages, the primary source of these pro-inflammatory molecules was evaluated. G1-4A was revealed to bind to the murine macrophages leading to their activation and reciprocally inhibited binding of LPS to macrophages. Following treatment with G1-4A, there was a small rise in serum TNF-alpha and IL-1beta levels. Though, challenge with lipopolysaccharide or LPS elicited significantly reduced levels of TNF-alpha in G1-4A pretreated mice as compared to the controls while the level of soluble TNFR was enhanced. An augment in serum IL-1beta, IL-6, IFN-gamma levels and decrease in that of IL-10 was observed following challenge with LPS or lipopolysaccharide in mice pretreated with G1-4A as compared to the controls. In addition, G1-4A also modulated the release of nitric oxide (NO3) by murine macrophages. Similar experience was observed in a human monocytic cell line, U937. Thus G1-4A appeared to induce tolerance against endotoxic shock by modulation of cytokines and nitric oxide.

Research II - Immunomodulatory role of Tinospora cordifolia (Guduchi) as an adjuvant in surgical treatment of diabetic foot ulcers: a prospective randomized controlled study.
By Purandare H, Supe A.

The research was conducted at Department of Surgery, Seth G. S. Medical College and K. E. M. Hospital, Mumbai, India.
BACKGROUND: Chronic diabetic mellitus patients with wounds have deficient growth factors and impaired local and systemic cellular immunity. Treatment with growth factors is costly with risk of infection transmission and these factors may not achieve best wound concentration. We evaluated the role of generalized immuno-modulation in diabetic ulcers by using Tinospora cordifolia (Giloy) as an adjuvant therapy and studied its influence on parameters or determinants of healing, on bacterial eradication and on polymorphonuclear phagocytosis.

MATERIALS AND METHODS: A prospective double-blind randomized controlled study lasting for over one and a half year in 50 patients. The ulcer was classified by wound morphology and severity with Wound Severity Score (Pecoraro-Reiber system). Mean ulcer area, depth and perimeter were deliberated and swabs taken for culture. Blood was composed to assess polymorphonuclear % phagocytosis (PMN function by Lehrer-Cline C. albicans method). Medical therapy, glycemic control, debridement, wound care were optimized. At 1 month, parameters were reassessed. PMN function was reviewed at 90 days.

RESULTS AND ANALYSIS: 45 patients completed the trial: study group - 23 (M:F = 17:1; mean age = 56.3 years; mean ulcer duration = 21.1 days); control group 22 (M:F = 19:3; mean age = 56.3 years; mean ulcer duration = 30.4 days). Net progress was seen in 17 patients (73.9%) in the study group; while in the control group, in 13 patients (59.1%); P = 0.292. Specific parameters incorporated rate of change of ulcer area - cm(2) /day (study - 0.15; control - 0.07; P = 0.145); rate of change of ulcer perimeter - mm/day (study - 0.09; control = - 0.07; P = 0.089); change of depth - mm (study - 2.2; control - 1.4; P = 0.096); change of wound score (study - 14.4; control - 10.6; P = 0.149); total number of debridements (study - 1.9; control - 2.5; P = 0.03) and change in % phagocytosis (study - 3.9; control - 2.3; P = 0.048).

CONCLUSION: Diabetic mellitus patients with foot ulcers on Tinospora cordifolia as an adjuvant therapy showed considerably better final outcome with improvement in wound healing. Reduced debridements and improved phagocytosis were statistically significant, indicating beneficial effects of immuno-modulation for ulcer healing.