Boswellia, or salai guggal extract is a standardized powder extract of the gum of the Boswellia tree (Boswellia serrata), containing a mixture of Boswellic acids. Boswellic acids are effective anti-inflammatory and anti-arthritic agents, for both osteoarthritis and rheumatoid art
hritis, soft tissue rheumatism, and low back pain.
Research conducted in India found that an extract of Boswellia was more beneficial, less toxic, and more potent than the standard drug of choice for rheumatic disorders
Observed benefits of Boswellia include reduction in joint swelling, increased mobility, steroid sparing action (less steroids required in combined treatment), less morning stiffness, improved grip strength, and general improvement in quality of life, for both osteoarthritis and rheumatoid arthritis.
In Ayurvedic medicine, different parts of Boswellia serrata were traditionally used to treat such varied health conditions as asthma, dysentery, rheumatism, ulcers, and skin disorders.
Extracts of the resin have shown unmistakable anti-inflammatory power in animals, and rats with experimental arthritis responded well to treatment without apparent side effects.
A boswellic acid mixture is used in India for arthritis treatment. A double-blind crossover study of patients with osteoarthritis demonstrated that a preparation containing Boswellia serrata significantly reduced disability scores and pain. Boswellia's anti-inflammatory properties can help to reduce aching and stiffness, especially when associated with low back pain. Boswellia can be taken internally as well as applied topically to affected joints to relieve inflammation associated with these joint disorders
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Serving size: 1 Vegi cap
Servings per container: 60
Each 250 mg capsule contains: Boswellia Extract
Dosage: 1 Capsules three times a day after meal or or as directed by your health practitioner.
Morpheme Shallaki is the highest quality, most potent and most effective form of Boswellia Extract available in Vegetable capsules. Free from Colour, Yeast, Gluten, Wheat, Corn and Dairy Products. Global leader in scientifically validated herbal medicines
The boswellic acids in Boswellia are active ingredients of the herb. All boswellic acids have a pentacyclic structure based on 12-ursen-24-oic acid with differing substituents. Many individual boswellic acid compounds have been isolated from the Boswellia extract including alpha and beta boswellic acids and derivatives. Boswellic acids have been shown to inhibit the production of certain inflammatory chemicals (leukotrienes) in the body. Boswellic acids have been found to have much the same effect as the nonsteroidal anti-inflammatory drugs (NSAIDS) typically prescribed for arthritis. Boswellic acids block white cell activity in damaged tissue, inhibiting the inflammatory response; and they also work to enhance blood flow to the joint region. Boswellic acids may interfere with enzymes that contribute to inflammation and pain.
Boswellia is a significant herb in the ayurvedic system of health and healing. Historically, the guggals were recommended by Ayurvedic physicians for a variety of conditions, including osteoarthritis, rheumatoid arthritis, diarrhea, dysentery, pulmonary disease, and ringworm. Boswellia is mainly used for its anti-inflammatory and antiarthritic properties. Boswellia may provide benefits for treating osteoarthritis and rheumatoid arthritis. Boswellia's anti-inflammatory properties can help to reduce aching and stiffness, especially when associated with low back pain. Boswellia can be taken internally as well as applied topically to affected joints to relieve inflammation associated with these joint disorders. Boswellia may improve symptoms of ulcerative colitis (inflammatory bowel disease), including abdominal pains, loose stools, and mucus and blood in the stools. Boswellia may also be beneficial in asthmatics and may also reduce fluid retention associated with brain tumours.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Phytomedicine. 2003 Jan;10(1):3-7.
Osteoarthritis is a common, chronic, progressive, skeletal, degenerative disorder, which commonly affects the knee joint. Boswellia serrata tree is commonly found in India. The therapeutic value of its gum has been known. It possesses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata extract in 30 patients of osteoarthritis of knee, 15 each receiving active drug or placebo for eight weeks. After the first intervention, washout was given and then the groups were crossed over to receive the opposite intervention for eight weeks. All patients receiving boswellia reported decrease in knee pain, increased knee flexion and increased walking distance. The frequency of swelling in the knee joint was decreased. Radiologically there was no change. The observed differences between drug treated and placebo being statistically significant, are clinically relevant. Boswellia serrata extract was well tolerated by the subjects except for minor gastrointestinal symptoms. Boswellia serrata extract is recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
Planta Med. 2001 Jul;67(5):391-5.
Patients studied here suffered from chronic colitis characterized by vague lower abdominal pain, bleeding per rectum with diarrhoea and palpable tender descending and sigmoid colon. The inflammatory process in colitis is associated with increased formation of leukotrienes causing chemotaxis, chemokinesis, synthesis of superoxide radicals and release of lysosomal enzymes by phagocytes. The key enzyme for leukotriene biosynthesis is 5-lipoxygenase. Boswellic acids were found to be non-redox, non-competitive specific inhibitors of the enzyme 5-lipoxygenase. We studied the gum resin of Boswellia serrata for the treatment of this disease. Thirty patients, 17 males and 13 females in the age range of 18 to 48 years with chronic colitis were included in this study. Twenty patients were given a preparation of the gum resin of Boswellia serrata (900 mg daily divided in three doses for 6 weeks) and ten patients were given sulfasalazine (3 gm daily divided in three doses for 6 weeks) and served as controls. Out of 20 patients treated with Boswellia gum resin 18 patients showed an improvement in one or more of the parameters: including stool properties, histopathology as well as scanning electron microscopy, besides haemoglobin, serum iron, calcium, phosphorus, proteins, total leukocytes and eosinophils. In the control group 6 out of 10 patients showed similar results with the same parameters. Out of 20 patients treated with Boswellia gum resin 14 went into remission while in case of sulfasalazine remission rate was 4 out of 10. In conclusion, this study shows that a gum resin preparation from Boswellia serrata could be effective in the treatment of chronic colitis with minimal side effects.
Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb
Indian J Exp Biol. 2003 Dec;41(12):1460-2.
Extract of gum resin of B. serrata containing 60% acetyl 11-keto beta boswellic acid (AKBA) along with other constituents such as 11-keto beta-boswellic acid (KBA), acetyl beta-boswellic acid and beta-boswellic acid has been evaluated for antianaphylactic and mast cell stabilizing activity using passive paw anaphylaxis and compound 48/80 induced degranulation of mast cell methods. The extract inhibited the passive paw anaphylaxis reaction in rats in dose-dependant manner (20, 40 and 80 mg/kg, po). However, the standard dexamethasone (0.27 mg/kg, po) revealed maximum inhibition of edema as compared to the extract. A significant inhibition in the compound 48/80 induced degranulation of mast cells in dose-dependant manner (20, 40 and 80 mg/kg, po) was observed thus showing mast cell stabilizing activity. The standard disodium cromoglycate (50 mg/kg, ip) was found to demonstrate maximum per cent protection against degranulation as compared to the extract containing 60% AKBA. The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract.
Boswellia, Boswellia Serrata, Shallaki, Joint Pain, Arthritis, Anti-Inflammatory, Herbal Supplement, Salai Guggul, Rheumatoid arthritis, Chronic colitis, Ulcerative colitis, Crohn's disease
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