Supplement Facts:

Serving size: 1 Vcap

Servings per container: 60

Each 250 mg capsule contains: Ashwagandha Extract 10:1

Dosage: 1-2 Capsules two times a day after meal or or as directed by your health practitioner.

Morpheme Ashvagandha is the highest quality, most potent and most effective form of Ashwagandha Extract available in Vegetable capsules. Free from Colour, Yeast, Gluten, Wheat, Corn and Dairy Products. Global leader in scientifically validated herbal medicines

Benefits Of Ashwagandha herb:

Clinical studies show that ashwagandha herb has antibacterial, antitumor, anti-inflammatory and immuno-modulating properties. A separate study also showed immunomodulatory (harmonizes immune function) effects, including a positive effect on the central nervous system.

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Reduces Stress:

Reduce stress and increase endurance. In one of several classic stress test experiments, a group of rats was given a saline solution and then tested for swimming times. A second group, given an ashwagandha solution, was able to swim twice as long. Some of the study authors caution that this result must be interpreted carefully, however. The ashwagandha root powders used to prepare the test solution contained starch, and at the high doses given in the swim studies, it is possible that these results were due to carbohydrate supplementation. Overall, however, animal studies do suggest that ashwagandha may help prevent stress-induced exhaustion.

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Antioxidant properties of Ashwagandha root

Researchers from Banaras Hindu University in Varanasi, India, have discovered that some of the chemicals within ashwagandha herb are powerful antioxidants. They tested these compounds for their effects on rat brain and found an increase in the levels of three natural antioxidants — superoxide dismutase, catalase and glutathione peroxidase. They say, "These findings are consistent with the therapeutic use of ashwagandha as an Ayurvedic rasayana (health promoter). The antioxidant effect of active principles of ashwagandha root may explain, at least in part, the reported anti-stress, cognition-facilitating, anti-inflammatory and anti-aging effects produced by them in experimental animals, and in clinical situations."

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Aphrodisiac properties of Ashwagandha Herb

Ashwagandha is historically used as an aphrodisiac. Ashwagandha is mentioned in the ancient Kama Sutra as an herb to be used for heightening sexual experience, Ashwagandha has the ability to restore sexual health and improve overall vitality while promoting a calm state of mind. It is a well known semen promoter and it treats impotency and infertility. It increases physical endurance and improves sexual function.

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Mental Problems Improved:

This is perhaps one of the most promising applications of this herb. In a reported study, this herb was given to 30 mental patients suffering from anxiety neurosis in doses of 40 ml/day. (in two equally divided doses.) for one month. At the end of the month, most of the anxiety disorders, panic attacks and similar mood phobias, had disappeared. In trials by American psychiatrists, this herb had been found useful for the treatment of manic depression, alcoholic paranoia, and schizophrenia. Up to 4 capsules were given daily, in between meals, for 45-60 days with very good results. Learning enhancement and memory retention had improved substantially when aswagandha (3 capsules), gotu kola (2 capsules), and ginkgo biloba (2 capsules) were taken regularly on a daily basis.

One reason for ashwagandha herb' reputation as a general energy-promoting, disease-preventing tonic may be its effect on the immune system. Multiple studies have shown significant increases in white blood cell counts and other measures of strengthened immunity in rodents given ashwagandha or certain chemicals extracted from the herb. Ashwagandha also has a mild sedative effect on the central nervous system, and has been shown in animal studies to be a muscle relaxant.

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Anti-Inflammatory Properties of Ashwagandha:

A methanolic extract of the aerial parts of Withania somnifera had antiinflammatory activities comparable to that of hydrocortisone sodium succinate (al-Hindawi et al 1992). An 80% ethanolic extract of Withania somnifera displayed significant antiinflammatory activity on carrageenan-induced paw edema (al-Hindawi 1989).

Ease arthritis. Although the mechanism is not fully understood, ashwagandha has been quite effective in relieving the inflammation associated with rheumatologic conditions such as arthritis. One clinical trial in humans supports this use. Forty-two patients with osteoarthritis were randomly placed in two groups--one receiving ashwagandha, one a placebo. After three months, pain and disability were markedly reduced in the ashwagandha group.

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Immune System:

Ashwagandha herb, like ginseng, also benefits the immune system and may have a significant role to play in the prevention and management of cancer. It may be able to limit the actual growth of cancer cells. In addition, research has shown that it can protect the activity of immune cells that are exposed to chemicals that would otherwise inhibit their normal function.2 This means that Ashwagandha could well reduce the side effects, including the suppression of white blood cells caused by radiation and chemotherapy.

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Research on Ashwagandha Herb

Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.

Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S.

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

The roots of Withania somnifera (WS) are used extensively in Ayurveda, the classical Indian system of medicine, and WS is categorized as a rasayana, which are used to promote physical and mental health, to provide defence against disease and adverse environmental factors and to arrest the aging process. WS has been used to stabilize mood in patients with behavioural disturbances. The present study investigated the anxiolytic and antidepressant actions of the bioactive glycowithanolides (WSG), isolated from WS roots, in rats. WSG (20 and 50 mg/kg) was administered orally once daily for 5 days and the results were compared by those elicited by the benzodiazepine lorazepam (0.5 mg/kg, i.p.) for anxiolytic studies, and by the tricyclic anti-depressant, imipramine (10 mg/kg, i.p.), for the antidepressant investigations. Both these standard drugs were administered once, 30 min prior to the tests. WSG induced an anxiolytic effect, comparable to that produced by lorazepam, in the elevated plus-maze, social interaction and feeding latency in an unfamiliar environment, tests. Further, both WSG and lorazepam, reduced rat brain levels of tribulin, an endocoid marker of clinical anxiety, when the levels were increased following administration of the anxiogenic agent, pentylenetetrazole. WSG also exhibited an antidepressant effect, comparable with that induced by imipramine, in the forced swim-induced 'behavioural despair' and 'learned helplessness' tests. The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda.

Scientific basis for the therapeutic use of Withania somnifera (ashwagandha):

Mishra LC, Singh BB, Dagenais S.

Los Angeles College of Chiropractic (LACC), 16200 E Amber Valley Dr., Whittier, CA 90609-1166. lakshmimishra@lacc.edu

OBJECTIVE: The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha, WS) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity.

DESIGN: This review is in a narrative format and consists of all publications relevant to ashwagandha that were identified by the authors through a systematic search of major computerized medical databases; no statistical pooling of results or evaluation of the quality of the studies was performed due to the widely different methods employed by each study.

RESULTS: Studies indicate ashwagandha possesses anti-inflammatory, antitumor, antistress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties. It also appears to exert a positive influence on the endocrine, cardiopulmonary, and central nervous systems.

The mechanisms of action for these properties are not fully understood.

Toxicity studies reveal that ashwagandha appears to be a safe compound.

CONCLUSION: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity. These results are very encouraging and indicate this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Clinical trials using ashwagandha for a variety of conditions should also be conducted.

Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation.

Agarwal R, Diwanay S, Patki P, Patwardhan B.

Bharati Vidyapeeth's Poona College of Pharmacy, Erandwane, Pune, India.

The immunomodulatory activities of an Indian Ayurvedic medicinal preparation, i.e. extracts from Ashwagandha, Withania somnifera (L.) Dunal (Solanaceae), namely WST and WS2, were studied in mice for immune inflammation: active paw anaphylaxis and delayed type hypersensitivity (DTH). Immunomodulatory effect was assessed in If IgE-mediated anaphylaxis as reduction of ovalbumin-induced paw edema, in animals treated with WS2 at doses of 150 and 300 mg/kg, and the results were compared with the standard drug disodium chromoglycate. In the DTH model, the modulatory effect was assessed as potentiation or suppression of the reaction, revealing an increase or decrease in mean foot pad thickness, respectively. Potentiation of the DTH reaction was observed in animals treated with cyclophosphamide at a dose of 20 mg/kg, WST at a dose of 1000 mg/kg and WS2 at a dose of 300 mg/kg. On the other hand, cyclophosphamide-induced potentiation of DTH reaction was suppressed in animals treated with WST and WS2. A significant increase in white blood cell counts and platelet counts was observed in animals treated with WST. A protective effect in cyclophosphamide-induced myelosuppression was observed in animals treated with WST and WS2, revealing a significant increase in white blood cell counts and platelet counts. Cyclophosphamide-induced immunosuppression was counteracted by treatment with WS2, revealing significant increase in hemagglutinating antibody responses and hemolytic antibody responses towards sheep red blood cells.

Ashwagandha herb, Withania Somnifera Supplements, Antidepressant, Stress related disorders such as Arthritis, Hypertension, Diabetes, General debility

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